TargetMol

Ac-FLTD-CMK

Product Code:
 
TAR-T36819
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36819-1mg1mg£309.00
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TAR-T36819-5mg5mg£656.00
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TAR-T36819-10mg10mg£863.00
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TAR-T36819-25mg25mg£1,299.00
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TAR-T36819-50mg50mg£1,661.00
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Quantity:
TAR-T36819-100mg100mg£2,303.00
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This product comes from: United States.
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Further Information

Bioactivity:
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is potent against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3[1].
CAS:
2376255-48-8
Formula:
C26H37ClN4O8
Molecular Weight:
569.05
Pathway:
Apoptosis|Proteases/Proteasome
Purity:
0.98
SMILES:
ClCC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CC(C)C)NC([C@@H](NC(C)=O)CC1=CC=CC=C1)=O)=O)=O)=O
Target:
Caspase

References

Jie Yang, et al. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A. 2018;115(26):6792-6797. Wang P, et al. Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injury. Neuroreport. 2021;32(3):188-197. Tian XX, et al. NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation. Int Endod J. 2021;54(6):916-925.