TargetMol

Geranylgeranyl Pyrophosphate (ammonium salt)

Product Code:
 
TAR-T36863
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T36863-1mg1mg£527.00
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TAR-T36863-5mg5mg£1,532.00
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Further Information

Bioactivity:
Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.[2] This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug discovery.[3][4]
CAS:
313263-08-0
Formula:
C20H45N3O7P2
Molecular Weight:
501.542
Purity:
0.98
SMILES:
[NH4+].[NH4+].[NH4+].CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCOP([O-])(=O)OP([O-])([O-])=O

References

Maynor, M., Scott, S.A., Rickert, E.L., et al. Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs. Bioorganic & Medicinal Chemistry Letters 18(6), 1889-1892 (2008). Baron, R.A., and Seabra, M.C. Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate. Biochemistry Journal 415(1), 67-75 (2008). McTaggart, S.J. Isoprenylated proteins. Cell Mol.Life Sci. 63(3), 255-267 (2006). Vance, D.E. Cholesterol and related derivatives. Biochemistry 2nd ed., 725-748 (1988).