TargetMol

9(Z),11(E),13(E)-Octadecatrienoic Acid methyl ester

Product Code:
 
TAR-T36889
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36889-1mg1mg£124.00
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TAR-T36889-5mg5mg£323.00
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TAR-T36889-10mg10mg£519.00
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Further Information

Bioactivity:
9Z,11E,13E-octadecatrienoic acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.
CAS:
4175-47-7
Formula:
C19H32O2
Molecular Weight:
292.5
Purity:
0.98
SMILES:
CCCC/C=C/C=CC=CCCCCCCCC(=O)OC