TargetMol

RA375

Product Code:
 
TAR-T36902
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-T36902-1mg1mg£118.00
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TAR-T36902-5mg5mg£189.00
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TAR-T36902-1mL1 mL * 10 mM (in DMSO)£230.00
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TAR-T36902-10mg10mg£269.00
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TAR-T36902-25mg25mg£406.00
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TAR-T36902-50mg50mg£549.00
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TAR-T36902-100mg100mg£764.00
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Further Information

Bioactivity:
RA375 is a inhibitor of RPN13 (26S proteasome regulatory subunit). RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead.
CAS:
0
Formula:
C30H25ClN4O7
Molecular Weight:
588.99
Pathway:
Ubiquitination; Proteases/Proteasome
Purity:
0.98
SMILES:
O=C(CCl)N[C@H](C(N1C/C(C(/C(C1)=C/C2=CC=C([N+]([O-])=O)C=C2)=O)=CC3=CC=C([N+]([O-])=O)C=C3)=O)CC4=CC=CC=C4
Target:
Proteasome

References

Ravi K Anchoori, et al. Structure-function Analyses of Candidate Small Molecule RPN13 Inhibitors With Antitumor Properties. PLoS One. 2020 Jan 15;15(1):e0227727.