TargetMol

SCH529074

Product Code:
 
TAR-T37042
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37042-1mg1mg£106.00
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TAR-T37042-2mg2mg£122.00
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TAR-T37042-5mg5mg£148.00
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TAR-T37042-1mL1 mL * 10 mM (in DMSO)£164.00
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TAR-T37042-10mg10mg£213.00
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TAR-T37042-25mg25mg£381.00
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TAR-T37042-50mg50mg£533.00
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TAR-T37042-100mg100mg£732.00
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Further Information

Bioactivity:
SCH529074 is a selective activator of p53 (Ki = 1 μM) and can be used in studies about non-small-cell lung carcinoma. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53.
CAS:
922150-11-6
Formula:
C31H36Cl2N6
Molecular Weight:
563.56
Pathway:
Apoptosis
Purity:
0.98
SMILES:
ClC1=CC=C(C=C1)C(C2=CC=C(Cl)C=C2)N3CCN(CC4=NC=5C=CC=CC5C(=N4)NCCCN(C)C)CC3
Target:
p53

References

Demma, M., Maxwell, E., Ramos, R., et al. SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53. J. Biol. Chem. 285(14), 10198-10212 (2010). Miljana Nenkov, et al. Growth Inhibitory Role of the p53 Activator SCH 529074 in non?small Cell Lung Cancer Cells Expressing Mutant p53. Oncol Rep. 2020 Jun;43(6):2073-2082.