TargetMol

12(S)-HETE

Product Code:
 
TAR-T37047
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37047-5mg5mg£1,492.00
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TAR-T37047-50mg50mg£2,946.00
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Quantity:
TAR-T37047-100mg100mg£4,006.00
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This product comes from: United States.
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Further Information

Bioactivity:
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. [1] It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1μM181M.[2][3]
CAS:
54397-83-0
Formula:
C20H32O3
Molecular Weight:
320.5
Purity:
0.98
SMILES:
CCCCC/C=CC[C@H](O)/C=C/C=CC/C=CCCCC(O)=O

References

Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Cancer Res. 49(4), 1029-1037 (1989). Hamberg, M., and Samuelsson, B. Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc. Natl. Acad. Sci. U.S.A. 71(9), 3400-3404 (1974). Honn, K.V., Nelson, K.K., Renaud, C., et al. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis. Prostaglandins 44(5), 413-429 (1992).