4,9-Anhydrotetrodotoxin

Product Code:

TAR-T37093

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

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Code	Size	Price

TAR-T37093-1mg

1mg

£1,393.00

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Further Information

Bioactivity:

4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). [1][2][3] It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 µM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.[1]

CAS:

13072-89-4

Formula:

C11H15N3O7

Molecular Weight:

301.3

Purity:

0.98

SMILES:

O[C@@]12[C@]3([H])[C@]4(N=C(N)N[C@@]([C@]45[H])([H])O3)[C@H](O)[C@@](O2)([H])[C@@](CO)(O)[C@]5([H])O1

Documents

References

Teramoto, N., and Yotsu-Yamashita, M. Selective blocking effects of 4,9-anhydrotetrodotoxin, purified from a crude mixture of tetrodotoxin analogues, on NaV1.6 channels and its chemical aspects. Mar.Drugs 13(2), 984-995 (2015). Rosker, C., Lohberger, B., Hofer, D., et al. The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Nav1.6 voltage-dependent sodium channel. American Journal of Physiology.Cell Physiology 293(2), C783-C789 (2007). Moczydlowski, E.G. The molecular mystique of tetrodotoxin. Toxicon 63, 165-183 (2013).