TargetMol

15(R)-15-methyl Prostaglandin D2

Product Code:
 
TAR-T37264
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T37264-5mg5mgEnquire
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TAR-T37264-1mg1mg£511.00
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Further Information

Bioactivity:
15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 . The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1 and CRTH2/DP2. 15(R)-15-methyl PGD2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 μM.
CAS:
210978-26-0
Formula:
C21H34O5
Molecular Weight:
366.498
Purity:
0.98
SMILES:
CCCCC[C@@](C)(O)C=C[C@@H]1[C@@H](CC=C/CCCC(O)=O)[C@@H](O)CC1=O