TargetMol

(±)-N-3-Benzylnirvanol

Product Code:
 
TAR-T37332
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37332-1mg1mg£111.00
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TAR-T37332-5mg5mg£168.00
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TAR-T37332-10mg10mg£249.00
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TAR-T37332-25mg25mg£430.00
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TAR-T37332-50mg50mg£581.00
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Quantity:
TAR-T37332-100mg100mg£782.00
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Quantity:
TAR-T37332-500mg500mg£1,508.00
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Quantity:
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Further Information

Bioactivity:
(?)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-benzylnirvanol and (-)-N-3-benzylnirvanol. (+)-N-3-benzylnirvanol and (-)-N-3-benzylnirvanol are inhibitors of the cytochrome P450 (CYP) isoform CYP2C19 (Kis = 0.292 and 5.3 μM, respectively). (?)-N-3-Benzylnirvanol (20 mg/kg, i.p.) lowers plasma levels of cholesterol in mice.
CAS:
93879-40-4
Formula:
C18H18N2O2
Molecular Weight:
294.4
Pathway:
Metabolism
Purity:
0.98
SMILES:
O=C(N1CC2=CC=CC=C2)C(C3=CC=CC=C3)(CC)NC1=O
Target:
P450

References

Suzuki H, et al. (+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19. Drug Metab Dispos. 2002;30(3):235-239. Barnette DA, et al, Swamidass SJ, Miller GP. Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam. Toxicol Lett. 2021;338:10-20.