TargetMol

6β-hydroxy Dexamethasone

Product Code:
 
TAR-T37361
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T37361-1mg1mg£495.00
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Further Information

Bioactivity:
6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans., The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.
CAS:
55879-47-5
Formula:
C22H29FO6
Molecular Weight:
408.466
Purity:
0.98
SMILES:
C[C@@H]1C[C@H]2[C@@H]3C[C@@H](O)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

References

Minagawa, K., Kasuya, Y., Baba, S., et al. Identification and quantification of 6 beta-hydroxydexamethasone as a major urinary metabolite of dexamethasone in man Steroids 47(2-3), 175-188 (1986). Gentile, D.M., Tomlinson, E.S., Maggs, J.L., et al. Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation J. Pharmacol. Exp. Ther. 277(1), 105-112 (1996). Zurbonsen, K., Bressolle, F., Solassol, I., et al. Simultaneous determination of dexamethasone and 6?-hydroxydexamethasone in urine using solid-phase extraction and liquid chromatography: Applications to in vivo measurement of cytochrome P450 3A4 activity J. Chomatogr. B Analyt. Technol. Biomed. Life Sci. 804(2), 421-429 (2004). Tomlinson, E.S., Maggs, J.L., Park, B.K., et al. Dexamethasone Metabolism in vitro: Species differences J. Steroid Biochem. Mol. Biol. 62(4), 345-352 (1997).