TargetMol

TRPC6-PAM-C20

Product Code:
 
TAR-T37428
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37428-1mg1mg£213.00
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TAR-T37428-5mg5mg£436.00
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TAR-T37428-1mL1 mL * 10 mM (in DMSO)£464.00
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TAR-T37428-10mg10mg£610.00
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TAR-T37428-25mg25mg£922.00
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TAR-T37428-50mg50mg£1,219.00
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Further Information

Bioactivity:
TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 with an EC50 of 2.37 μM. TRPC6-PAM-C20 enhances OAG-induced platelet aggregation.
CAS:
667427-75-0
Formula:
C22H21NO4
Molecular Weight:
363.413
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
COc1cc2CC(C)(C)N=C(c2cc1OC)c1cc2ccccc2oc1=O
Target:
TRP/TRPV Channel

References

H?fner S, Urban N, Schaefer M. Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels. Cell Calcium. 2019 Mar;78:26-34.