TargetMol

Galanin (Human) (Acetate)

Product Code:
 
TAR-T38110
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T38110-1mg1mg£375.00
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Further Information

Bioactivity:
Human galanin is a 30-amino acid neuropeptide and galanin (GAL) receptor agonist.1,2,3,4It inhibits forskolin-induced cAMP production in HEK293E cells expressing recombinant human GAL1receptors (EC50= 0.031 nM) and stimulates inositol phosphate accumulation in CHO cells expressing recombinant human GAL2receptors (EC50= 12.3 nM).1,2Human galanin induces contractions in isolated rat longitudinal fundus strips with an EC50value of 13.8 nM.3Intrathecal administration of human galanin (3, 10, and 30 nmol/animal) reduces paw licking and flinching in the second, but not first, phase of the formalin test in rats.4
CAS:
0
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0

References

Fitzgerald, L.W., Patterson, J.P., Conklin, D.S., et al.Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: Agonist character of chimeric galanin peptidesJ. Pharmacol. Exp. Ther.287(2)448-456(1998) Borowsky, B., Walker, M.W., Huang, L.Y., et al.Cloning and characterization of the human galanin GALR2 receptorPeptides19(10)1771-1781(1998) Schmidt, W.E., Kratzin, H., Eckart, K., et al.Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptideProc. Natl. Acad. Sci. USA88(24)11435-11439(1991)