TargetMol

CAY10597

Product Code:
 
TAR-T38365
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T38365-1mg1mg£139.00
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TAR-T38365-5mg5mg£390.00
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TAR-T38365-10mg10mg£640.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10597, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM. The R enantiomer is slightly more potent exhibiting Ki values of 23 and 22 nM at the human and murine CRTH2/DP2 receptor, respectively. The R enantiomer of CAY10597 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-prostaglandin D2 with an IC50 value of 40 nM.
CAS:
916046-55-4
Formula:
C20H14ClFN2O5
Molecular Weight:
416.8
Purity:
0.98
SMILES:
OC(=O)CN1c2ccc(Cl)cc2C2(CC(=O)N(Cc3ccccc3F)C2=O)C1=O