TargetMol

Picropodophyllotoxin

Product Code:
 
TAR-T3S0027
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3S0027-1mg1mg£96.00
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TAR-T3S0027-5mg5mg£130.00
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TAR-T3S0027-1mL1 mL * 10 mM (in DMSO)£136.00
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TAR-T3S0027-10mg10mg£148.00
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TAR-T3S0027-25mg25mg£222.00
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TAR-T3S0027-50mg50mg£319.00
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TAR-T3S0027-100mg100mg£445.00
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Further Information

Bioactivity:
Picropodophyllin is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells.
CAS:
17434-18-3
Formula:
C22H22O8
Molecular Weight:
414.41
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.9957
SMILES:
COc1cc(cc(OC)c1OC)[C@H]1[C@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12
Target:
IGF-1R

References

Rui-Hong F , Hai-Yan Y , Zhi-Qing M A , et al. Study on 6 insecticidal podophyllotoxin compounds from the berries of Sabina vulgaris Ant[J]. Journal of Northwest A & F University, 2007, 35(9):117-122.