TargetMol

Aristolactam I

Product Code:
 
TAR-T3S1227
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3S1227-1mg1mg£115.00
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TAR-T3S1227-5mg5mg£185.00
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TAR-T3S1227-1mL1 mL * 10 mM (in DMSO)£219.00
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TAR-T3S1227-10mg10mg£254.00
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TAR-T3S1227-25mg25mg£383.00
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TAR-T3S1227-50mg50mg£531.00
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TAR-T3S1227-100mg100mg£726.00
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Further Information

Bioactivity:
1. Aristololactam I has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I may be mediated by different mechanisms except TGF-beta1 pathway. 3. Aristololactam I may be one of toxic metabolites in Chinese herbs containing AA which participate in renal damage and fibrosis.
CAS:
13395-02-3
Formula:
C17H11NO4
Molecular Weight:
293.278
Pathway:
Proteases/Proteasome; Apoptosis
Purity:
0.9963
SMILES:
COc1cccc2c1cc1NC(=O)c3cc4OCOc4c2c13
Target:
Apoptosis; Caspase

References

Li J , Zhang L , Jiang Z , et al. Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells[J]. Toxicology in Vitro, 2010, 24(4):0-1097.