TargetMol

SAG dihydrochloride

Product Code:
 
TAR-T40465
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T40465-1mg1mg£118.00
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TAR-T40465-5mg5mg£148.00
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TAR-T40465-10mg10mg£195.00
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TAR-T40465-1mL1 mL * 10 mM (in DMSO)£262.00
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TAR-T40465-25mg25mg£281.00
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Quantity:
TAR-T40465-50mg50mg£389.00
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Quantity:
TAR-T40465-100mg100mg£547.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist ( EC 50 =3 nM; K d =59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo.
CAS:
0
Formula:
0
Molecular Weight:
0
Pathway:
Stem Cells|GPCR/G Protein
Purity:
0.98
SMILES:
0
Target:
Hedgehog/Smoothened

References

Guerrini G, et, al. Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration. J Cell Physiol. 2018 Dec; 233(12): 9799-9811. Fish EW, et al. Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice. Birth Defects Res A Clin Mol Teratol. 2016 Nov 1. Stanton BZ, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5(3):154-6. Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6. Lee S, et al. Combining Smoothened Agonist (SAG) and NEL-like protein-1 (NELL-1) Enhances Bone Healing. Plast Reconstr Surg. 2017 Feb 13.