TargetMol

AST 487

Product Code:
 
TAR-T4053
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4053-1mg1mg£95.00
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TAR-T4053-2mg2mg£106.00
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TAR-T4053-5mg5mg£128.00
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TAR-T4053-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T4053-10mg10mg£168.00
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TAR-T4053-25mg25mg£229.00
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TAR-T4053-50mg50mg£369.00
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TAR-T4053-100mg100mg£517.00
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TAR-T4053-500mg500mg£1,050.00
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Further Information

Bioactivity:
AST 487 is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.
CAS:
630124-46-8
Formula:
C26H30F3N7O2
Molecular Weight:
529.568
Pathway:
Tyrosine Kinase/Adaptors; Apoptosis; Angiogenesis; Cytoskeletal Signaling
Purity:
0.9956
SMILES:
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1
Target:
VEGFR; FLT; c-RET; Bcr-Abl; c-Kit

References

Weisberg E, et al. Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cells. Blood. 2008 Dec 15;112(13):5161-70. Akeno-Stuart N, et al. The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells. Cancer Res. 2007 Jul 15;67(14):6956-64. Agarwal N, Zhou Q, Arya D, et al. AST-487 Inhibits RET Kinase Driven TERT Expression in Bladder Cancer. International Journal of Molecular Sciences. 2022, 23(18): 10819.