TargetMol

ML-60218

Product Code:
 
TAR-T40661
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T40661-1mg1mg£111.00
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TAR-T40661-2mg2mg£130.00
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TAR-T40661-5mg5mg£168.00
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TAR-T40661-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T40661-10mg10mg£229.00
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TAR-T40661-25mg25mg£436.00
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TAR-T40661-50mg50mg£610.00
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TAR-T40661-100mg100mg£838.00
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This product comes from: United States.
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Further Information

Bioactivity:
ML-60218 is an inhibitor of broad-spectrum RNA pol III with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and hampers the formation of new viroplasms.
CAS:
577784-91-9
Formula:
C19H15Cl2N3O2S2
Molecular Weight:
452.37
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
0.98
SMILES:
Cc1c(sc2ccc(Cl)cc12)-c1cc(NS(=O)(=O)c2ccccc2Cl)n(C)n1
Target:
DNA/RNA Synthesis

References

Wei W, Zhang S, Han H, et al.NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer.Cell Reports.2023, 42(7). Eichwald C, et al. Identification of a Small Molecule That Compromises the Structural Integrity of Viroplasms and Rotavirus Double-Layered Particles. J Virol. 2018;92(3):e01943-17. Published 2018 Jan 17. Yee NS, et al. Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer. Biol Open. 2012;1(4):295-307. Wu L, et al. Novel small-molecule inhibitors of RNA polymerase III. Eukaryot Cell. 2003;2(2):256-264.