TargetMol

PF-06282999

Product Code:
 
TAR-T4090
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4090-1mg1mg£95.00
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TAR-T4090-2mg2mg£105.00
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TAR-T4090-5mg5mg£128.00
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TAR-T4090-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T4090-10mg10mg£168.00
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TAR-T4090-25mg25mg£269.00
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TAR-T4090-50mg50mg£389.00
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Quantity:
TAR-T4090-100mg100mg£544.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potentially useful for the treatment of cardiovascular diseases.
CAS:
1435467-37-0
Formula:
C13H12ClN3O3S
Molecular Weight:
325.77
Pathway:
Metabolism
Purity:
0.9828
SMILES:
COc1ccc(Cl)cc1-c1cc(=O)[nH]c(=S)n1CC(N)=O
Target:
Glutathione Peroxidase

References

Ruggeri RB, et al. Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-062821999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases. J Med Chem. 20 Dong JQ, et al. Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans. Drug Metab Dispos. 2016 Feb;44(2):209-19.