TargetMol

AFN-1252

Product Code:
 
TAR-T4105
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4105-1mg1mg£103.00
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TAR-T4105-2mg2mg£118.00
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TAR-T4105-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T4105-5mg5mg£148.00
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TAR-T4105-10mg10mg£195.00
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TAR-T4105-25mg25mg£303.00
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TAR-T4105-50mg50mg£426.00
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TAR-T4105-100mg100mg£595.00
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Further Information

Bioactivity:
AFN-1252(Debio 1452) is an effective inhibitor of enoyl-acyl carrier protein reductase (FabI). It (?0.12 μg/ml) inhibits all Clinicalal isolates of Staphylococcus aureus and Staphylococcus epidermidis.
CAS:
620175-39-5
Formula:
C22H21N3O3
Molecular Weight:
375.428
Pathway:
; Microbiology/Virology
Purity:
0.9909
SMILES:
CN(Cc1oc2ccccc2c1C)C(=O)C=CC1=CNC2=NC(=O)CCC2=C1
Target:
Antibacterial; Antibiotic

References

Yao J, et al. Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI). J Biol Chem. 2013 Dec 20;288(51):36261-71. Karlowsky JA, et al. AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. Antimicrob Agents Chemother. 2009 Aug;53(8):3544-8. Parsons JB, et al. Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252. Antimicrob Agents Chemother. 2013 May;57(5):2182-90. Narasimha Rao K, et al. AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei-Crystal structure, mode of action, and biological activity. Protein Sci. 2015 May;24(5):832-40.