TargetMol

Diffractaic Acid

Product Code:
 
TAR-T4114
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T4114-1mL1 mL * 10 mM (in DMSO)£414.00
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Quantity:
TAR-T4114-20mg20mg£661.00
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Further Information

Bioactivity:
Diffractaic Acid can inhibit LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells with activity value of 8 μM.
CAS:
436-32-8
Formula:
C20H22O7
Molecular Weight:
374.389
Pathway:
Apoptosis; Immunology/Inflammation
Purity:
0.9981
SMILES:
COc1cc(C)c(C(=O)Oc2cc(C)c(C(O)=O)c(O)c2C)c(OC)c1C
Target:
Apoptosis; LTR

References

Kumar KC, et al. Lichen metabolites. 1. Inhibitory action against leukotriene B4 biosynthesis by a non-redox mechanism. J Nat Prod. 1999 Jun;62(6):817-20. Kal?n ? N, Altay A, Budak H. Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells. Chemico-Biological Interactions. 2022: 109984 Budak B, Kal?n ? N, Yap?a ? E.Antiproliferative, antimigratory, and apoptotic effects of diffractaic and vulpinic acids as thioredoxin reductase 1 inhibitors on cervical cancer.Naunyn-Schmiedeberg's Archives of Pharmacology.2023: 1-11. G?nayd?n ?, Suluko?lu E K, Kal?n ? N, et al.Diffractaic acid exhibits thioredoxin reductase 1 inhibition in lung cancer A549 cells.Journal of Applied Toxicology.2023;1?10.