TargetMol

SP-96

Product Code:
 
TAR-T41256
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T41256-1mg1mg£124.00
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TAR-T41256-5mg5mg£201.00
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TAR-T41256-1mL1 mL * 10 mM (in DMSO)£213.00
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TAR-T41256-10mg10mg£282.00
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TAR-T41256-25mg25mg£483.00
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TAR-T41256-50mg50mg£670.00
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Quantity:
TAR-T41256-100mg100mg£914.00
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Further Information

Bioactivity:
SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negative breast cancer studies.
CAS:
2682114-54-9
Formula:
C25H20FN7O
Molecular Weight:
453.47
Pathway:
Cell Cycle/Checkpoint; Chromatin/Epigenetic
Purity:
0.9932
SMILES:
Cn1ncc(-c2ccc3c(Nc4cccc(NC(Nc5cccc(F)c5)=O)c4)ncnc3c2)c1
Target:
Aurora Kinase

References

Naga Rajiv Lakkaniga,et al. Discovery of SP-96, the first non-ATP-competitive Aurora Kinase B inhibitor, for reduced myelosuppression.Eur J Med Chem. 2020 Jul 12;203:112589.