TargetMol

PTP1B-IN-2

Product Code:
 
TAR-T4256
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4256-1mg1mg£111.00
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TAR-T4256-5mg5mg£168.00
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TAR-T4256-10mg10mg£209.00
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TAR-T4256-1mL1 mL * 10 mM (in DMSO)£217.00
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TAR-T4256-25mg25mg£349.00
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TAR-T4256-50mg50mg£490.00
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Quantity:
TAR-T4256-100mg100mg£680.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM).
CAS:
1919853-46-5
Formula:
C34H36N2O9S2
Molecular Weight:
680.79
Pathway:
Metabolism
Purity:
0.9958
SMILES:
COC(=O)CN(c1ccc(CN(c2ccc(OCc3ccc(C)cc3)c(c2)C(=O)OC)S(=O)(=O)Cc2ccccc2)cc1)S(C)(=O)=O
Target:
Phosphatase

References

Wu R, Wang C, Li Z, et al. SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell-mediated cytotoxicity that can be reversed by SAHA[J]. Journal for immunotherapy of cancer. 2020, 8(2). Liu P, et al. Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity. Eur J Med Chem. 2016 Aug 8;118:27-33. Wu R, Wang C, Li Z, et al. SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell-mediated cytotoxicity that can be reversed by SAHA. Journal for immunotherapy of cancer. 2020 Nov;8(2):e001037.