TargetMol

Osilodrostat

Product Code:
 
TAR-T4277
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4277-1mg1mg£105.00
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TAR-T4277-2mg2mg£119.00
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TAR-T4277-1mL1 mL * 10 mM (in DMSO)£130.00
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TAR-T4277-5mg5mg£139.00
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TAR-T4277-10mg10mg£172.00
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TAR-T4277-25mg25mg£237.00
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TAR-T4277-50mg50mg£393.00
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TAR-T4277-100mg100mg£550.00
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Further Information

Bioactivity:
Osilodrostat (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).
CAS:
928134-65-0
Formula:
C13H10FN3
Molecular Weight:
227.242
Pathway:
Metabolism; ; Endocrinology/Hormones
Purity:
0.9912
SMILES:
Fc1cc(ccc1[C@H]1CCc2cncn12)C#N
Target:
Glucocorticoid Receptor; Hydroxylase

References

Li L, et al. Osilodrostat (LCI699), a potent 11?-hydroxylase inhibitor, administered in combination with the multireceptor-targeted somatostatin analog pasireotide: A 13-week study in rats. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):224-33. Fleseriu M, et al. Osilodrostat, a potent oral 11?-hydroxylase inhibitor: 22-week, prospective, Phase II study in Cushing's disease. Pituitary. 2016 Apr;19(2):138-48.