TargetMol

AM966

Product Code:
 
TAR-T4278
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4278-2mg2mg£98.00
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TAR-T4278-5mg5mg£115.00
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TAR-T4278-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T4278-10mg10mg£142.00
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TAR-T4278-25mg25mg£201.00
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TAR-T4278-50mg50mg£294.00
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TAR-T4278-100mg100mg£430.00
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TAR-T4278-500mg500mg£872.00
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This product comes from: United States.
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Further Information

Bioactivity:
AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
CAS:
1228690-19-4
Formula:
C27H23ClN2O5
Molecular Weight:
490.94
Pathway:
GPCR/G Protein
Purity:
0.9949
SMILES:
C[C@@H](OC(=O)Nc1c(C)noc1-c1ccc(cc1)-c1ccc(CC(O)=O)cc1)c1ccccc1Cl
Target:
LPA Receptor; LPL Receptor

References

Olianas MC, et al. Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts. Biochem Pharmacol. 2015 Ju Swaney, JS, et al. A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model. Br J Pharmacol. 2010 Aug;160(7):1699-713.