TargetMol

S-methyl-KE-298

Product Code:
 
TAR-T4282
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4282-1mg1mg£345.00
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TAR-T4282-5mg5mg£688.00
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TAR-T4282-1mL1 mL * 10 mM (in DMSO)£698.00
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TAR-T4282-10mg10mg£978.00
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TAR-T4282-25mg25mg£1,420.00
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TAR-T4282-50mg50mg£1,910.00
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Quantity:
TAR-T4282-100mg100mg£2,456.00
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This product comes from: United States.
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Further Information

Bioactivity:
S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from ?rheumatoid arthritis (RA) synovial cells.
CAS:
143584-75-2
Formula:
C13H16O3S
Molecular Weight:
252.33
Pathway:
Metabolism; Proteases/Proteasome
Purity:
0.969
SMILES:
CSCC(CC(=O)c1ccc(C)cc1)C(O)=O
Target:
MMP; Drug Metabolite

References

Honda S, et al. Expression of membrane-type 1 matrix metalloproteinase in rheumatoid synovial cells. Clin Exp Immunol. 2001 Oct;126(1):131-6. Yoshida H , Kohno Y , Endo H , et al. Identification of metabolites of KE-298, a new antirheumatic drug, and its physiological properties in rats.[J]. Biological & Pharmaceutical Bulletin, 1996, 19(3):424-9. Yoshida H , Kohno Y , Endo H , et al. Stereoselective disposition and chiral inversion of KE-298, a new antirheumatic drug, in rats[J]. Chirality, 2015, 9(1):22-28.