TargetMol

Tropifexor

Product Code:
 
TAR-T4379
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4379-1mg1mg£142.00
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TAR-T4379-5mg5mg£206.00
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TAR-T4379-1mL1 mL * 10 mM (in DMSO)£251.00
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TAR-T4379-10mg10mg£280.00
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TAR-T4379-25mg25mg£440.00
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TAR-T4379-50mg50mg£633.00
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TAR-T4379-100mg100mg£922.00
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TAR-T4379-200mg200mg£1,356.00
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TAR-T4379-500mg500mg£1,974.00
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Further Information

Bioactivity:
Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
CAS:
1383816-29-2
Formula:
C29H25F4N3O5S
Molecular Weight:
603.59
Pathway:
Autophagy; Metabolism
Purity:
0.9985
SMILES:
OC(=O)c1cc(F)c2nc(sc2c1)N1[C@H]2CC[C@@H]1C[C@@H](C2)OCc1c(onc1-c1ccccc1OC(F)(F)F)C1CC1
Target:
FXR; Autophagy

References

Tully DC,etal.Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).J Med Chem. 2017 Dec 28;60(24):9960-9973.