TargetMol

PF-4840154

Product Code:
 
TAR-T4385
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4385-1mg1mg£160.00
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TAR-T4385-2mg2mg£199.00
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TAR-T4385-5mg5mg£345.00
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TAR-T4385-1mL1 mL * 10 mM (in DMSO)£356.00
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TAR-T4385-10mg10mg£470.00
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TAR-T4385-25mg25mg£707.00
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TAR-T4385-50mg50mg£978.00
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TAR-T4385-100mg100mg£1,291.00
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Further Information

Bioactivity:
PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.
CAS:
1332708-14-1
Formula:
C26H38N6O2
Molecular Weight:
466.63
Pathway:
Membrane transporter/Ion channel
Purity:
0.9848
SMILES:
CC(C)CNc1nc(ncc1C(=O)NCc1ccccc1)N1CCN(CC2CCCOC2)CC1
Target:
TRP/TRPV Channel

References

Ryckmans T,etal.Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel.Bioorg Med Chem Lett. 2011 Aug 15;21(16):4857-9.