TargetMol

GSK2879552 2HCl (1401966-69-5(free base))

Product Code:
 
TAR-T4418
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4418-1mg1mg£114.00
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TAR-T4418-2mg2mg£133.00
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TAR-T4418-1mL1 mL * 10 mM (in DMSO)£160.00
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TAR-T4418-5mg5mg£160.00
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TAR-T4418-10mg10mg£219.00
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TAR-T4418-25mg25mg£318.00
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TAR-T4418-50mg50mg£418.00
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TAR-T4418-100mg100mg£586.00
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TAR-T4418-500mg500mg£1,171.00
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This product comes from: United States.
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Further Information

Bioactivity:
GSK2879552 is an orally available, irreversible inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
CAS:
T4418
Formula:
C23H30Cl2N2O2
Molecular Weight:
437.41
Pathway:
Chromatin/Epigenetic
Purity:
0.9988
SMILES:
Cl.Cl.OC(=O)c1ccc(CN2CCC(CN[C@@H]3C[C@H]3c3ccccc3)CC2)cc1
Target:
Histone Demethylase

References

Mohammad HP,etal.A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.Cancer Cell. 2015 Jul 13;28(1):57-69. Huang M,etal.Targeting KDM1A attenuates Wnt/?-catenin signaling pathway to eliminate sorafenib-resistant stem-like cells in hepatocellular carcinoma.Cancer Lett. 2017 Jul 10;398:12-21. Lv S, Zhao X, Zhang E, et al. Lysine demethylase KDM1A promotes cell growth via FKBP8-BCL2 axis in hepatocellular carcinoma. Journal of Biological Chemistry. 2022: 102374.