TargetMol

Nemorubicin

Product Code:
 
TAR-T4469
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4469-1mg1mg£111.00
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TAR-T4469-5mg5mg£168.00
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TAR-T4469-10mg10mg£229.00
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TAR-T4469-25mg25mg£436.00
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TAR-T4469-50mg50mg£610.00
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TAR-T4469-100mg100mg£838.00
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This product comes from: United States.
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Further Information

Bioactivity:
Nemorubicin is a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives.
CAS:
108852-90-0
Formula:
C32H37NO13
Molecular Weight:
643.642
Purity:
0.9779
SMILES:
CO[C@@H]1CN(CCO1)[C@H]1C[C@H](O[C@H]2C[C@@](O)(Cc3c(O)c4C(=O)c5cccc(OC)c5C(=O)c4c(O)c23)C(=O)CO)O[C@@H](C)[C@H]1O

References

Quintieri L, et al. In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: a comparison with human liver microsomes. Biochem Pharmacol. 2008 Sep 15;76(6):784-95. Lu H, et al. Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer. Cancer Gene Ther. 2009 May;16(5):393-404.