TargetMol

Licochalcone D

Product Code:
 
TAR-T4518
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4518-1mg1mg£148.00
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TAR-T4518-5mg5mg£309.00
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TAR-T4518-1mL1 mL * 10 mM (in DMSO)£333.00
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TAR-T4518-10mg10mg£426.00
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TAR-T4518-25mg25mg£647.00
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TAR-T4518-50mg50mg£867.00
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TAR-T4518-100mg100mg£1,139.00
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Further Information

Bioactivity:
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotective potential against myocardial ischemia/reperfusion injury in langendorff-perfused rat hearts. Licochalcone D has anti-inflammatory activity, it shows suppression ability of nitric oxide (NO) production. Licochalcone D has anti-allergic activity, it suppresses degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells.
CAS:
144506-15-0
Formula:
C21H22O5
Molecular Weight:
354.402
Pathway:
NF-κb; MAPK
Purity:
0.9903
SMILES:
COc1c(O)c(O)ccc1C=CC(=O)c1ccc(O)c(CC=C(C)C)c1
Target:
ERK; NF-κB

References

Wang P, et al. Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells[J]. Molecular Medicine Reports, 2015, 12(5):7623. Yuan X, et al. Cardioprotective Effect of Licochalcone D against Myocardial Ischemia/Reperfusion Injury in Langendorff-Perfused Rat Hearts[J]. Plos One, 2015, 10(6):e20128375. Tanifuji S, et al. Licochalcones suppress degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells.[J]. International Immunopharmacology, 2010, 10(7):769-776. Kim S J, et al. Synthesis of licochalcone analogues with increased anti-inflammatory activity[J]. Bioorganic & Medicinal Chemistry Letters, 2014, 24(1):181-185.