TargetMol

Hinokiflavone

Product Code:
 
TAR-T4S0181
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T4S0181-50mg50mgEnquire
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TAR-T4S0181-1mg1mg£102.00
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TAR-T4S0181-5mg5mg£161.00
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TAR-T4S0181-10mg10mg£205.00
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TAR-T4S0181-25mg25mg£298.00
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Further Information

Bioactivity:
Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spliceosome assembly, specifically preventing B complex formation. Hinokiflavone is a SUMO protease inhibitor, inhibiting sentrin-specific protease 1 (SENP1) activity.Hinokiflavone has significant cytotoxicity, it has inhibition of MMP-9.
CAS:
19202-36-9
Formula:
C30H18O10
Molecular Weight:
538.464
Pathway:
Ubiquitination; Apoptosis; Proteases/Proteasome
Purity:
0.9867
SMILES:
Oc1ccc(cc1)-c1cc(=O)c2c(O)c(Oc3ccc(cc3)-c3cc(=O)c4c(O)cc(O)cc4o3)c(O)cc2o1
Target:
MMP; BCL; E1/E2/E3 Enzyme

References

Xiao Y, Cai G P, Feng X, et al.Splicing factor YBX1 regulates bone marrow stromal cell fate during aging.The EMBO Journal.2023: e111762. Huang W , Liu C , Liu F , et al. Hinokiflavone induces apoptosis and inhibits migration of breast cancer cells via EMT signalling pathway[J]. Cell Biochemistry and Function, 2020, 38(11).