TargetMol

Prunetin

Product Code:
 
TAR-T4S0878
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T4S0878-50mg50mgEnquire
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TAR-T4S0878-1mg1mg£102.00
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TAR-T4S0878-1mL1 mL * 10 mM (in DMSO)£140.00
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TAR-T4S0878-10mg10mg£195.00
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TAR-T4S0878-25mg25mg£282.00
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Further Information

Bioactivity:
1. Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. 3. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones. 4. Prunetin significantly suppresses ATP-induced mucin secretion from cultured RTSE cells; Prunetin inhibits the production of MUC5AC mucin protein induced by EGF or PMA from NCI-H292 cells; Prunetin also inhibits the expression of MUC5AC mucin gene induced by EGF or PMA from NCI-H292 cells.
CAS:
552-59-0
Formula:
C16H12O5
Molecular Weight:
284.267
Pathway:
NF-κb; Metabolism; MAPK
Purity:
0.98
SMILES:
COc1cc(O)c2c(c1)occ(-c1ccc(O)cc1)c2=O
Target:
ERK; Dehydrogenase; NF-κB

References

Yang G , Ham I , Choi H Y . Anti-inflammatory effect of prunetin via the suppression of NF-?B pathway[J]. Food & Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association, 2013, 58:124-132.