TargetMol

Obtusifolin

Product Code:
 
TAR-T4S0969
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4S0969-1mg1mg£122.00
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TAR-T4S0969-1mL1 mL * 10 mM (in DMSO)£229.00
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TAR-T4S0969-5mg5mg£229.00
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TAR-T4S0969-10mg10mg£306.00
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TAR-T4S0969-25mg25mg£470.00
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TAR-T4S0969-50mg50mg£627.00
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TAR-T4S0969-100mg100mg£859.00
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Further Information

Bioactivity:
1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be a novel anti-breast-cancer bone metastasis agent. 3. Obtusifolin has beneficial effects on the development of diabetic retinopathy via inhibition of accumulation of oxidatively modified DNA and nitrotyrosine in the retina, can help prevent vision loss in diabetic patients. 4. Obtusifolin and gluco-Obtusifolin produce significant antinociceptive action in rodent behavioral models of inflammatory/neuropathic pain, and that this activity is associated with modulation of neuroinflammation in spinal cord. 5. Gluco-Obtusifolin and its aglycone may be useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, by the enhancement of cholinergic signaling.
CAS:
477-85-0
Formula:
C16H12O5
Molecular Weight:
284.267
Pathway:
NF-κb; oxidation-reduction
Purity:
0.9979
SMILES:
COc1c(O)c(C)cc2C(=O)c3cccc(O)c3C(=O)c12
Target:
Antioxidant; NF-κB

References

Hsu Y L , Tsai E M , Hou M F , et al. Obtusifolin Suppresses Phthalate Esters-Induced Breast Cancer Bone Metastasis by Targeting Parathyroid Hormone-Related Protein[J]. Journal of Agricultural & Food Chemistry, 2014, 62(49):11933-40.