TargetMol

TIQ-A

Product Code:
 
TAR-T50098
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T50098-1mg1mg£132.00
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TAR-T50098-5mg5mg£201.00
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TAR-T50098-1mL1 mL * 10 mM (in DMSO)£209.00
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TAR-T50098-10mg10mg£303.00
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TAR-T50098-25mg25mg£503.00
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TAR-T50098-50mg50mg£687.00
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Quantity:
TAR-T50098-100mg100mg£863.00
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Quantity:
TAR-T50098-500mg500mg£1,741.00
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This product comes from: United States.
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Further Information

Bioactivity:
TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis.
CAS:
420849-22-5
Formula:
C11H7NOS
Molecular Weight:
201.24
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.98
SMILES:
O=c1[nH]c2sccc2c2ccccc12
Target:
PARP

References

Chiarugi A, et al. Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia. J Pharmacol Exp Ther. 2003 Jun;305(3):943-9.