TargetMol

Tofogliflozin (hydrate)

Product Code:
 
TAR-T5016
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5016-1mg1mg£101.00
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TAR-T5016-2mg2mg£114.00
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TAR-T5016-5mg5mg£142.00
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TAR-T5016-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T5016-10mg10mg£185.00
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TAR-T5016-25mg25mg£290.00
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TAR-T5016-50mg50mg£466.00
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TAR-T5016-100mg100mg£623.00
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TAR-T5016-200mg200mg£854.00
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TAR-T5016-500mg500mg£1,219.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tofogliflozin hydrate is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2).
CAS:
1201913-82-7
Formula:
C22H28O7
Molecular Weight:
404.459
Pathway:
Immunology/Inflammation; GPCR/G Protein; NF-κb; Metabolism
Purity:
0.9878
SMILES:
O.CCc1ccc(Cc2ccc3CO[C@]4(O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c3c2)cc1
Target:
SGLT; Reactive Oxygen Species; ROS

References

Ishibashi Y, et al. Tofogliflozin, A Highly Selective Inhibitor of SGLT2 Blocks Proinflammatory and Proapoptotic Effects of Glucose Overload on Proximal Tubular Cells Partly by Suppressing Oxidative Stress Generation. Horm Metab Res. 2016 Mar;48(3):191-5. Suzuki M, et al. Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701.