TargetMol

IRAK inhibitor 1

Product Code:
 
TAR-T5094
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5094-1mg1mg£140.00
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TAR-T5094-2mg2mg£173.00
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TAR-T5094-1mL1 mL * 10 mM (in DMSO)£181.00
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TAR-T5094-5mg5mg£242.00
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TAR-T5094-10mg10mg£309.00
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TAR-T5094-25mg25mg£470.00
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TAR-T5094-50mg50mg£651.00
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TAR-T5094-100mg100mg£863.00
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Further Information

Bioactivity:
IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM).
CAS:
1042224-63-4
Formula:
C17H19N5
Molecular Weight:
293.374
Pathway:
NF-κb; Immunology/Inflammation; MAPK
Purity:
0.9778
SMILES:
C1CC(CCN1)Nc1cccc(n1)-c1cnc2ccccn12
Target:
IRAK; JNK

References

Buckley GM, et al. IRAK-4 inhibitors. Part II: A structure-based assessment of imidazo[1,2-a]pyridine binding. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3291-5.