TargetMol

TGN-020

Product Code:
 
TAR-T5102
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5102-5mg5mg£108.00
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Quantity:
TAR-T5102-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T5102-10mg10mg£132.00
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TAR-T5102-25mg25mg£184.00
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TAR-T5102-50mg50mg£250.00
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Quantity:
TAR-T5102-100mg100mg£357.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
TGN-020 is an inhibitor of Aquaporin 4 (AQP4, IC50: 3.1 μM), the most abundant water channel in the brain.
CAS:
51987-99-6
Formula:
C8H6N4OS
Molecular Weight:
206.22
Pathway:
Membrane transporter/Ion channel
Purity:
0.9954
SMILES:
O=C(Nc1nncs1)c1cccnc1
Target:
Aquaporin

References

Igarashi H, et al. Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport. 2013 Apr 17;24(6):324-8. Guo S, Song Z, He J, et al. Akt/aquaporin-4 signaling aggravates neuropathic pain by activating astrocytes after spinal nerve ligation in rats. Neuroscience. 2021 Huber VJ, et al. Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg Med Chem. 2009 Jan 1;17(1):411-7.