TargetMol

Brilanestrant

Product Code:
 
TAR-T5118
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5118-1mg1mg£109.00
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TAR-T5118-2mg2mg£127.00
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TAR-T5118-5mg5mg£157.00
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TAR-T5118-1mL1 mL * 10 mM (in DMSO)£174.00
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TAR-T5118-10mg10mg£193.00
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TAR-T5118-25mg25mg£290.00
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Quantity:
TAR-T5118-50mg50mg£432.00
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Quantity:
TAR-T5118-100mg100mg£590.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
GDC-0810 is a selective estrogen receptor degrader (IC50: 0.7 nM).
CAS:
1365888-06-7
Formula:
C26H20ClFN2O2
Molecular Weight:
446.91
Pathway:
Endocrinology/Hormones
Purity:
0.9871
SMILES:
CCC(=C(c1ccc(C=CC(O)=O)cc1)c1ccc2[nH]ncc2c1)c1ccc(F)cc1Cl
Target:
Estrogen Receptor/ERR; Estrogen/progestogen Receptor

References

Joseph JD, et al. The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer. Elife. 2016 Jul 13;5. pii: e15828. doi: 10.7554/eLife.15828. By Lai, et al. Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts. J Med Chem. 2015 Jun 25;58(12):4888-904.