TargetMol

dBET6

Product Code:
 
TAR-T5130
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5130-1mg1mg£109.00
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TAR-T5130-5mg5mg£149.00
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TAR-T5130-1mL1 mL * 10 mM (in DMSO)£198.00
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TAR-T5130-10mg10mg£209.00
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TAR-T5130-25mg25mg£330.00
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TAR-T5130-50mg50mg£487.00
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TAR-T5130-100mg100mg£672.00
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TAR-T5130-500mg500mg£1,332.00
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Further Information

Bioactivity:
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
CAS:
1950634-92-0
Formula:
C42H45ClN8O7S
Molecular Weight:
841.38
Pathway:
Chromatin/Epigenetic; Apoptosis
Purity:
0.9912
SMILES:
Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCCCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1
Target:
Apoptosis; Epigenetic Reader Domain

References

Shi Y, Liao Y, Liu Q, et al.BRD4-targeting PROTAC as a unique tool to study biomolecular condensates.Cell Discovery.2023, 9(1): 1-13. Winter GE, et al. BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment. Mol Cell. 2017 Jul 6;67(1):5-18.e19.