TargetMol

MKT-077

Product Code:
 
TAR-T5152
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5152-1mg1mg£95.00
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TAR-T5152-5mg5mg£139.00
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TAR-T5152-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T5152-10mg10mg£191.00
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TAR-T5152-25mg25mg£275.00
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TAR-T5152-50mg50mg£399.00
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TAR-T5152-100mg100mg£497.00
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This product comes from: United States.
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Further Information

Bioactivity:
MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 μM in vitro) through its ability to inhibit members of the Hsp70 family of molecular chaperones.
CAS:
147366-41-4
Formula:
C21H22ClN3OS2
Molecular Weight:
432
Pathway:
Metabolism; Cytoskeletal Signaling
Purity:
0.982
SMILES:
[Cl-].CCn1c(=Cc2cccc[n+]2CC)sc(=C2Sc3ccccc3N2C)c1=O
Target:
HSP

References

Weisberg EL, et al. In vivo administration of MKT-077 causes partial yet reversible impairment of mitochondrial function. Cancer Res. 1996 Feb 1;56(3):551-5. Li X, et al. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013 Nov 14;4(11). Starenki D, et al. Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo. Endocrinol Metab (Seoul). 2015 Dec;30(4):593-603.