TargetMol

EGFR-IN-12

Product Code:
 
TAR-T5168
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5168-1mg1mg£131.00
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TAR-T5168-5mg5mg£201.00
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TAR-T5168-1mL1 mL * 10 mM (in DMSO)£213.00
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TAR-T5168-10mg10mg£289.00
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TAR-T5168-25mg25mg£510.00
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TAR-T5168-50mg50mg£696.00
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Quantity:
TAR-T5168-100mg100mg£922.00
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TAR-T5168-500mg500mg£1,773.00
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This product comes from: United States.
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Further Information

Bioactivity:
EGFR inhibitor is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.
CAS:
879127-07-8
Formula:
C21H18F3N5O
Molecular Weight:
413.404
Pathway:
JAK/STAT signaling; Angiogenesis; Tyrosine Kinase/Adaptors; Apoptosis
Purity:
0.9915
SMILES:
FC(F)(F)c1cccc(Nc2cc(Nc3cccc(NC(=O)C4CC4)c3)ncn2)c1
Target:
Apoptosis; EGFR

References

Zhang Q, et al. Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. J Am Chem Soc. 2006 Feb 22;128(7):2182-3.