TargetMol

azd1390

Product Code:
 
TAR-T5175
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5175-1mg1mg£135.00
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TAR-T5175-5mg5mg£201.00
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TAR-T5175-1mL1 mL * 10 mM (in DMSO)£209.00
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TAR-T5175-10mg10mg£262.00
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TAR-T5175-25mg25mg£462.00
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TAR-T5175-50mg50mg£570.00
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TAR-T5175-100mg100mg£711.00
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Further Information

Bioactivity:
AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes.
CAS:
2089288-03-7
Formula:
C27H32FN5O2
Molecular Weight:
477.584
Pathway:
PI3K/Akt/mTOR signaling; DNA Damage/DNA Repair
Purity:
0.9938
SMILES:
CC(C)n1c2c(cnc3cc(F)c(cc23)-c2ccc(OCCCN3CCCCC3)nc2)n(C)c1=O
Target:
ATM/ATR

References

Durant ST, et al. The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models. Sci Adv. 2018 Jun 20;4(6):eaat1719.