TargetMol

MK-3903

Product Code:
 
TAR-T5187
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5187-1mg1mg£100.00
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TAR-T5187-2mg2mg£113.00
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TAR-T5187-5mg5mg£148.00
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TAR-T5187-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T5187-10mg10mg£213.00
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TAR-T5187-25mg25mg£335.00
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TAR-T5187-50mg50mg£497.00
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TAR-T5187-100mg100mg£687.00
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TAR-T5187-500mg500mg£1,340.00
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Further Information

Bioactivity:
MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).
CAS:
1219737-12-8
Formula:
C27H19ClN2O3
Molecular Weight:
454.91
Pathway:
PI3K/Akt/mTOR signaling; Chromatin/Epigenetic
Purity:
0.9863
SMILES:
Cc1ccc(Oc2nc3cc(Cl)c(cc3[nH]2)-c2ccc(cc2)-c2ccccc2)cc1C(O)=O
Target:
AMPK

References

Lan P, et al. Hit-to-Lead Optimization and Discovery of 5-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase. J Med Chem. 2017 Nov 9;60(21):9040-9052.