TargetMol

COH000

Product Code:
 
TAR-T5199
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5199-1mg1mg£254.00
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TAR-T5199-2mg2mg£335.00
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TAR-T5199-5mg5mg£462.00
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TAR-T5199-1mL1 mL * 10 mM (in DMSO)£497.00
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TAR-T5199-10mg10mg£603.00
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TAR-T5199-25mg25mg£970.00
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TAR-T5199-50mg50mg£1,452.00
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TAR-T5199-100mg100mg£2,070.00
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Further Information

Bioactivity:
COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).
CAS:
1534358-79-6
Formula:
C25H25NO5
Molecular Weight:
419.477
Pathway:
Ubiquitination
Purity:
0.9691
SMILES:
[H][C@]12O[C@@](C=C1)([C@@H](Cc1ccc(C)cc1)Nc1ccccc1)C(C(=O)OC)=C2C(=O)OC
Target:
E1/E2/E3 Enzyme

References

Li YJ, et al. Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme. Cell Chem Biol. 2018 Dec 5. pii: S2451-9456(18)30386-6. Sun B, Wu H, Lu J, et al. Irisin reduces bone fracture by facilitating osteogenesis and antagonizing TGF-?/Smad signaling in a growing mouse model of osteogenesis imperfecta. Journal of Orthopaedic Translation. 2023, 38: 175-189.