TargetMol

MRT68921 HCl

Product Code:
 
TAR-T5356
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5356-1mg1mg£111.00
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TAR-T5356-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T5356-5mg5mg£119.00
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TAR-T5356-10mg10mg£147.00
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TAR-T5356-25mg25mg£230.00
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TAR-T5356-50mg50mg£358.00
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TAR-T5356-100mg100mg£429.00
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This product comes from: United States.
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Further Information

Bioactivity:
MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 nM, respectively).
CAS:
2070014-87-6
Formula:
C25H35ClN6O
Molecular Weight:
471.05
Pathway:
Autophagy
Purity:
0.9986
SMILES:
Cl.CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc2C1
Target:
Autophagy

References

Skah S, et al. cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53. Oncotarget. 2018 Jul 13;9(54):30434-30449. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83.