TargetMol

DDR1-IN-2

Product Code:
 
TAR-T5402
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5402-1mg1mg£106.00
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TAR-T5402-5mg5mg£148.00
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TAR-T5402-1mL1 mL * 10 mM (in DMSO)£173.00
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TAR-T5402-10mg10mg£211.00
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TAR-T5402-25mg25mg£364.00
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TAR-T5402-50mg50mg£518.00
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TAR-T5402-100mg100mg£725.00
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TAR-T5402-500mg500mg£1,380.00
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This product comes from: United States.
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Further Information

Bioactivity:
DDR1-IN-2 (DDR1 inhibitor 7rh) is a potent, selective, ATP-competitive Discoidin domain receptor 1 (DDR1) inhibitor (IC50: 6.8 nM in cell-free kinase assays).
CAS:
1429617-90-2
Formula:
C30H29F3N6O
Molecular Weight:
546.598
Pathway:
Tyrosine Kinase/Adaptors
Purity:
1
SMILES:
CCc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Target:
Discoidin Domain Receptor (DDR)

References

Gao M, et al. Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. J Med Chem. 2013 Apr 25;56(8):3281-95. Aguilera KY, et al. Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther. 2017 Nov;16(11):2473-2485.