TargetMol

SNAP 94847

Product Code:
 
TAR-T5406
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5406-1mg1mg£111.00
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Quantity:
TAR-T5406-1mL1 mL * 10 mM (in DMSO)£156.00
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TAR-T5406-5mg5mg£156.00
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TAR-T5406-10mg10mg£201.00
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TAR-T5406-25mg25mg£345.00
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Quantity:
TAR-T5406-50mg50mg£475.00
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Further Information

Bioactivity:
SNAP-94847 is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM). It has anxiolytic and antidepressant activity and reduces food intake in mice.
CAS:
487051-12-7
Formula:
C29H32F2N2O2
Molecular Weight:
478.57
Pathway:
Endocrinology/Hormones; GPCR/G Protein
Purity:
0.98
SMILES:
CC(C(Nc1cc(C2CCN(CC2)Cc3ccc(Oc4cc(F)c(F)cc4)cc3)c(C)cc1)=O)C
Target:
GPR; Melanin-concentrating Hormone Receptor (MCHR)

References

Ye H, et al. Melanin-Concentrating Hormone (MCH) and MCH-R1 in the Locus Coeruleus May Be Involved in the Regulation of Depressive-Like Behavior. Int J Neuropsychopharmacol. 2018 Dec 1;21(12):1128-1137. Marsteller DA, et al. The MCH1 receptor antagonist SNAP 94847 induces sensitivity to dopamine D2/D3 receptor agonists in rats and mice. Eur J Pharmacol. 2009 Jan 5;602(1):66-72. Chen CA, et al. Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits. J Med Chem. 2007 Aug 9;50(16):3883-90.