TargetMol

PF-AKT400

Product Code:
 
TAR-T5508
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5508-1mg1mg£148.00
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TAR-T5508-5mg5mg£262.00
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TAR-T5508-1mL1 mL * 10 mM (in DMSO)£282.00
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TAR-T5508-10mg10mg£346.00
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TAR-T5508-25mg25mg£536.00
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TAR-T5508-50mg50mg£736.00
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Quantity:
TAR-T5508-100mg100mg£994.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-AKT400 is a broadly selective and ATP-competitive inhibitor of Akt.
CAS:
1004990-28-6
Formula:
C20H22F2N6O
Molecular Weight:
400.434
Pathway:
PI3K/Akt/mTOR signaling; Cytoskeletal Signaling
Purity:
0.9982
SMILES:
CCc1c[nH]c2ncnc(N3CC[C@](N)(CNC(=O)c4ccc(F)cc4F)C3)c12
Target:
Akt

References

Freeman-Cook KD, et al. Design of selective, ATP-competitive inhibitors of Akt. J Med Chem. 2010 Jun 24;53(12):4615-4622. Chen SF, et al. Binding selectivity studies of PKB? using molecular dynamics simulation and free energy calculations. J Mol Model. 2013 Nov;19(11):5097-5112.