TargetMol

Aurora kinase inhibitor-3

Product Code:
 
TAR-T5524
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5524-1mg1mg£132.00
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TAR-T5524-2mg2mg£165.00
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TAR-T5524-5mg5mg£230.00
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TAR-T5524-1mL1 mL * 10 mM (in DMSO)£252.00
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TAR-T5524-10mg10mg£334.00
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TAR-T5524-25mg25mg£515.00
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TAR-T5524-50mg50mg£704.00
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TAR-T5524-100mg100mg£930.00
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TAR-T5524-200mg200mg£1,219.00
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Further Information

Bioactivity:
Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.
CAS:
879127-16-9
Formula:
C21H18F3N5O
Molecular Weight:
413.404
Pathway:
Cell Cycle/Checkpoint; Chromatin/Epigenetic
Purity:
0.98
SMILES:
FC(F)(F)c1cccc(Nc2ccnc(Nc3cccc(NC(=O)C4CC4)c3)n2)c1
Target:
Aurora Kinase

References

Tari L W , Hoffman I D , Bensen D C , et al. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors[J]. Bioorganic and Medicinal Chemistry Letters, 2007, 17(3):688-691. Zhang Q , Liu Y , Gao F , et al. Discovery of EGFR Selective 4,6-Disubstituted Pyrimidines from a Combinatorial Kinase-Directed Heterocycle Library[J]. Journal of the American Chemical Society, 2006, 128(7):2182-2183.